Association of hyperuricemia with risk of incident chronic kidney disease in adult in Songjiang district, Shanghai: a follow-up study
10.3760/cma.j.cn112338-20200719-00957
- VernacularTitle:上海市松江区成年人高尿酸血症与慢性肾病关系的队列研究
- Author:
Yun QIU
1
;
Qi ZHAO
;
Na WANG
;
Shuheng CUI
;
Yuting YU
;
Yonggen JIANG
;
Genming ZHAO
Author Information
1. 复旦大学公共卫生学院流行病学教研室，公共卫生安全教育部重点实验室，上海 200032
- Keywords:
Chronic kidney disease;
Serum uric acid;
Hyperuricemia;
Cohort study
- From:
Chinese Journal of Epidemiology
2021;42(9):1607-1614
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the association of hyperuricemia with the risk for chronic kidney disease (CKD) in community adults.Methods:A community-based follow-up study comprising of 7 276 adults aged 20-74 years who attended the natural population cohort in Eastern China and had no CKD at baseline survey was performed in the Songjiang district, Shanghai. CKD was diagnosed according to the National Kidney Foundation Practice Guidelines for Chronic Kidney Disease criteria. Hyperuricemia was defined as serum uric acid level >420 μmol/L for men and >360 μmol/L for women. Cox proportional hazards model was used to examine the association of hyperuricemia with the risk for CKD.Results:During a median follow-up period of 2.65 year, 301 participants were newly diagnosed with CKD. The cumulative incidence rate and incidence density of CKD were 4.14%, and 16.01/1 000 person-years (95% CI: 14.20-17.82), respectively. A higher prevalence of hyperuricemia was observed in subjects with CKD compared with those without CKD. Multivariate Cox regression model analysis showed that hyperuricemia was associated with the increased risk for CKD, with an adjusted HR of 1.92 (95% CI: 1.46-2.53). Their positive associations remained in almost all the subgroups, including sex, age (<60, ≥60 years), BMI (<25.0, ≥25.0 kg/m 2), type 2 diabetes, and hypertension. A significant synergistic effect of the interaction between age and hyperuricemia on CKD was found, and the synergy index was 1.78 (95% CI: 1.18-2.68). Conclusion:The incidence of CKD in adults in Songjiang district was relatively high. Hyperuricemia is an independent risk factor for the development of CKD.
