Gene-body mass index interaction on coronary heart disease in Chinese adult twins
10.3760/cma.j.cn112338-20201130-01362
- VernacularTitle:基于中国双生子人群的冠心病遗传-BMI交互作用研究
- Author:
Yu'e XI
1
;
Wenjing GAO
;
Jun LYU
;
Canqing YU
;
Shengfeng WANG
;
Tao HUANG
;
Dianjianyi SUN
;
Chunxiao LIAO
;
Zengchang PANG
;
Min YU
;
Hua WANG
;
Xianping WU
;
Zhong DONG
;
Fan WU
;
Guohong JIANG
;
Xiaojie WANG
;
Yu LIU
;
Jian DENG
;
Lin LU
;
Weihua CAO
;
Liming LI
Author Information
1. 北京大学公共卫生学院流行病与卫生统计学系 100191
- Keywords:
Coronary heart disease;
Body mass index;
Gene-environment interaction;
Twin study
- From:
Chinese Journal of Epidemiology
2021;42(9):1573-1579
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the gene-body mass index (BMI) interaction on coronary heart disease (CHD) in the Chinese adult twins.Methods:A total of 20 340 same-sex twin pairs registered in the Chinese National Twin Registry (CNTR) were enrolled in this study. Classical twin structure equation model was used to estimate the gene-BMI interaction on CHD.Results:After adjusting for age, we found that genetic variance of CHD differed as the function of BMI in male twins, which indicated the presence of a gene-BMI interaction on CHD ( P=0.008).The genetic moderating effect ( βa) was -0.14 (95% CI: -0.22--0.04), indicating that for each logarithmic transformation value of BMI increase, genetic path parameters would decrease by 0.14, which would result in the decrease of genetic variance of CHD. And the heritability of CHD was 0.77 (95% CI: 0.65-0.86) among the male twins with lower BMI (<24.0 kg/m 2), but 0.56 (95% CI: 0.33-0.74) among the male twins with high BMI (≥24.0 kg/m 2). However, there was no evidence suggesting that BMI could moderate genetic variants of CHD in female. Conclusion:We found a significant gene-BMI interaction on CHD in the Chinese male adult twins in China, and the heritability of CHD was higher among the twins whose BMI was <24.0 kg/m 2.
