Immunity persistence of 60 μg high dose hepatitis B vaccine and influencing factors in maintained hemodialysis patients
10.3760/cma.j.cn112338-20210319-00221
- VernacularTitle:维持性血液透析患者60 μg高剂量乙型肝炎疫苗免疫持久性及影响因素
- Author:
Yuanting WU
1
;
Tian YAO
;
Jing SHI
;
Jianmin WANG
;
Guangming LIU
;
Fuzhen WANG
;
Yongliang FENG
;
Suping WANG
Author Information
1. 山西医科大学公共卫生学院流行病学教研室，太原 030001
- Keywords:
Maintained hemodialysis patients;
Hepatitis B vaccine;
Immune persistence;
Influence factors;
Interaction
- From:
Chinese Journal of Epidemiology
2021;42(9):1566-1572
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the anti-HBs level in maintained hemodialysis patients one year after receiving 20 μg and 60 μg hepatitis B vaccination at 0, 1 and 6 months, and explore the influence factors for the immunity persistence and their interactions.Methods:Based on a randomized controlled trial of 20 μg and 60 μg hepatitis B vaccine immunization in maintained hemodialysis patients at 0, 1, and 6 months, follow up was conducted for the patients for one year after the completion of the vaccination for the quantitative detection of anti-HBs, and χ 2 test, t test, unconditional logistic regression and interaction analyses were used for statistical analysis. Results:One year after the vaccination, 125 and 124 patients in the 20 μg and 60 μg groups were tested for anti-HBs, respectively. The positive rate of anti-HBs in the 60 μg group (77.42%, 96/124) was significantly higher than that in the 20 μg group (65.60%, 82/125) ( P<0.05). After adjusting for the confounding factors, the positive probability of anti-HBs in the 60 μg group was 1.925 times higher than that in the 20 μg group (95% CI: 1.068-3.468). Patients with hemodialysis duration ≥5 years ( OR=0.523, 95% CI: 0.293-0.935) and diabetes mellitus ( OR=0.376, 95% CI: 0.173-0.818) had lower positive probability of anti-HBs. Moreover, there were additive and multiplicative interactions between hemodialysis duration ≥5 years and diabetes mellitus. Conclusions:The immunity persistence after one year in 60 μg hepatitis B vaccination group was longer than that in 20 μg hepatitis B vaccination group in maintained hemodialysis patients, vaccine dose, hemodialysis duration and diabetes mellitus were the influencing factors for the immunity persistence, there were additive and multiplicative interactions between hemodialysis duration ≥5 years and diabetes mellitus.
