Development and outlook on human challenge trial of vaccine
- VernacularTitle:疫苗人体挑战试验的发展与展望
- Author:
Bingfeng HAN
1
;
Ninghua HUANG
;
Linyi CHEN
;
Tianshuo ZHAO
;
Hanyu LIU
;
Sihui ZHANG
;
Yu WANG
;
Hui ZHENG
;
Bei LIU
;
Chao WANG
;
Yaqiong LIU
;
Qingbin LU
;
Fuqiang CUI
Author Information
- Keywords: Human challenge trial; Vaccine; COVID-19
- From: Chinese Journal of Epidemiology 2021;42(8):1371-1375
- CountryChina
- Language:Chinese
- Abstract: Human challenge trial (HCT) is a test in which human volunteers are intentionally infected with pathogens in order to evaluate the efficacy of candidate preventive or therapeutic drugs. During the COVID-19 pandemic, the HCT of vaccines has aroused people's attention due to its significant advantages over clinical trial. This paper introduces the concept, development and application of HCT, the advantages and limitations of HCT for vaccine evaluation, and the consideration of future HCT of COVID-19 vaccine in China.
