Comparison of Fried phenotype and frailty index and their associations with risk of mortality
10.3760/cma.j.cn112338-20210310-00192
- VernacularTitle:Fried表型和衰弱指数与死亡风险关联的比较分析
- Author:
Junning FAN
1
;
Zhijia SUN
;
Canqing YU
;
Yu GUO
;
Dianjianyi SUN
;
Pei PEI
;
Huaidong DU
;
Junshi CHEN
;
Zhengming CHEN
;
Jun LYU
;
Liming LI
Author Information
1. 北京大学公共卫生学院/北京大学公众健康与重大疫情防控战略研究中心/北京大学分子心血管学教育部重点实验室 100191
- Keywords:
Fried phenotype;
Frailty index;
Mortality;
Prospective cohort study;
Chinese;
Adult
- From:
Chinese Journal of Epidemiology
2021;42(7):1179-1187
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the consistency of frailty status measured by Fried phenotype and frailty index composed of different numbers of deficits, and their prospective associations with risk of mortality.Methods:Data of 23 615 participants from the second resurvey of the China Kadoore Biobank (CKB) was used. Fried phenotype was constructed using five phenotypes, and frailty indexes (FI) were constructed using 28 and 40 deficits, respectively. We calculated the Weighted Kappa coefficient to compare the consistency of three measures in the classification of frailty status. Cox regression was performed to analyze the association of frailty status with risk of mortality.Results:The frailty prevalence calculated by Fried phenotype, FI-28, and FI-40 were 5.4%, 7.9%, and 4.0%, respectively. The Kappa coefficients of Fried phenotype with FI-28 and FI-40 were 0.357 and 0.408, respectively. The Kappa coefficients of FI-28 and FI-40 was 0.712. During an average of (3.9±0.5) years of follow-up, 755 participants died. When Fried phenotype was used, compared with the robust participants, the prefrail and frail participants had increased risk of mortality, the multivariable-adjusted HRs were 1.60 (95% CI: 1.32-1.94) and 2.90 (95% CI: 2.25-3.73), respectively. When FI-28 was used, the corresponding HRs were 1.71 (95% CI: 1.39-2.11) and 2.52 (95% CI:1.95-3.27) for prefrail and frail participants, and when FI-40 was used, the corresponding HRs were 1.98 (95% CI:1.60-2.44) and 3.71 (95% CI: 2.80-4.91). The association of frailty status with mortality differed in different age groups, with the association stronger in younger adults than in older adults. Conclusion:Fried phenotype and frailty index constituted with different numbers of deficits showed good consistency; which can be used to well predict the risk of mortality.
