Modification of physical activity on genetic effects of type 2 diabetes mellitus: a twin pairs cohort study in China
- VernacularTitle:体力活动对2型糖尿病遗传效应的修饰作用——中国双生子队列研究
- Author:
Songjian CHEN
1
;
Wenjing GAO
;
Jun LYU
;
Canqing YU
;
Shengfeng WANG
;
Tao HUANG
;
Dianjianyi SUN
;
Chunxiao LIAO
;
Zengchang PANG
;
Min YU
;
Hua WANG
;
Xianping WU
;
Zhong DONG
;
Fan WU
;
Guohong JIANG
;
Xiaojie WANG
;
Yu LIU
;
Jian DENG
;
Lin LU
;
Weihua CAO
;
Liming LI
Author Information
- Keywords: Diabetes mellitus, type 2; Twin study; Gene-environment interaction
- From: Chinese Journal of Epidemiology 2021;42(7):1167-1173
- CountryChina
- Language:Chinese
- Abstract: Objective:To explore the modification effect of physical activity on the genetic effects of type 2 diabetes mellitus (T2DM).Methods:The univariate moderation model was fitted to calculate the modifying effect of physical activity on the genetic effects of T2DM based on the data of 12 107 pairs of same gender twins aged 30 years and older enrolled by the Chinese National Twin Registry in 11 provinces/cities in China.Results:After adjusting for age and gender, the heritability of T2DM was 0.56 (0.31-0.84). Qualified physical activity could attenuate the genetic effects of T2DM. The heritability of T2DM in twin pairs with qualified physical activity was 0.46 (0.06-0.88), which was lower than that in twin pairs without qualified physical activity during the same model [0.68(0.36-0.94)].Conclusion:T2DM is a moderate genetic disease, physical activity can modify the genetic effects of T2DM.
