Prognosis of high-risk HPV infection and its influences by vaginal micro-environmental factors
10.3760/cma.j.cn112338-20200829-01107
- VernacularTitle:高危型人乳头瘤病毒感染的转归特点及阴道微环境因子对其转归影响的研究
- Author:
Dan MENG
1
;
Li SONG
;
Zhuo QI
;
Jie WANG
;
Hong LIU
;
Yuanjing LYU
;
Haixia JIA
;
Ling DING
;
Min HAO
;
Zhiqiang TIAN
;
Jintao WANG
Author Information
1. 山西医科大学公共卫生学院流行病学教研室，太原 030001
- Keywords:
Vaginal micro-environmental factors;
High-risk human papillomavirus;
Prognosis
- From:
Chinese Journal of Epidemiology
2021;42(6):1103-1107
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To describe the characteristics of high-risk human papillomavirus (HR-HPV) infection and its influences by vaginal micro-environmental factors.Methods:A total of 421 women with HR-HPV infection and normal cervix diagnosed by pathology were selected from a community cohort established earlier by our research group for a 24-month follow-up. The baseline data were collected at enrollment. The vaginal micro-environmental factors were detected by using the combined detection kit of aerobic vaginitis and bacterial vaginosis. And the HPV was detected by using the flow-through hybridization technology. According to the HR-HPV infection status in baseline and 24 months of follow-up, with the prognosis characteristics of HR-HPV infection described, the impact of vaginal micro-environmental factors on the prognosis of HR-HPV infection was explored as well.Results:Among 390 HR-HPV infected women who completed 24 months of follow-up, the top five types of persistent HR-HPV infection rate appeared as HPV16 (24.1%), HPV58 (22.2%), HPV53 (21.7%), HPV52 (20.0%), and HPV39 (11.8%), respectively. The results showed that women with abnormal vaginal pH (a OR=1.74, 95% CI: 1.08-2.80), abnormal neuraminidase (a OR=2.70, 95% CI: 1.52-4.83), or abnormal leucocyte esterase (a OR=3.41, 95% CI: 2.13-5.44), the risk of HR-HPV persistent infection increased. The abnormalities of neuraminidase and leukocyte esterase could increase the risk of persistent infection of homotype and heterotypic HR-HPV. Conclusions:HPV16 was prone to persistent infection. Abnormalities of vaginal pH, neuraminidase, and leukocyte esterase might increase the risk of HR-HPV persistent infection. Both the abnormalities of neuraminidase and leukocyte esterase play an essential role in the HR-HPV persistent infection.
