Effect of dietary water-soluble vitamins on the poor prognosis of low-grade cervical intraepithelial neoplasia-a prospective cohort study
10.3760/cma.j.cn112338-20200807-01040
- VernacularTitle:膳食水溶性维生素对低度宫颈上皮内瘤变转归影响的前瞻性队列研究
- Author:
Hong LIU
1
;
Li SONG
;
Zhuo QI
;
Dan MENG
;
Jie WANG
;
Yuanjing LYU
;
Haixia JIA
;
Ling DING
;
Min HAO
;
Zhiqiang TIAN
;
Jintao WANG
Author Information
1. 山西医科大学公共卫生学院流行病学教研室，太原 030001
- Keywords:
Dietary water-soluble vitamins;
Low-grade cervical intraepithelial neoplasia;
Prognosis;
Cohort study
- From:
Chinese Journal of Epidemiology
2021;42(6):1097-1102
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the effect of dietary water-soluble vitamins on the poor prognosis of low-grade cervical intraepithelial neoplasia (CINⅠ).Methods:A total of 564 participants with CINⅠ were selected from a community-based married women cohort established in 2014. The general baseline information was collected, and HPV genotyping was detected. A food frequency questionnaire was used to investigate dietary water-soluble vitamins' consumption and determine their exposure levels. The follow-up program was carried out for 12 months, and the regression, persistence, and progression of CINⅠ was determined according to histopathological results at 12-month.Results:The low-levels of dietary water-soluble vitamins could promote CINⅠ's persistence and progression, showing the increasing tendency of CINⅠ poor prognosis with the decrease of water-soluble vitamin levels. Especially folate, VB1, VB2, VB6, niacin, biotin, and VC ( RR values were 15.22, 1.86, 1.92, 2.11, 2.98, 2.14, 2.19, respectively) played an important role. Considering the status of high-risk human papillomavirus (HR-HPV) infection, our results showed that the low levels of folate, niacin, biotin could promote the poor prognosis of CINⅠ. Conclusions:The low-level of dietary water-soluble vitamins could facilitate the poor prognosis of CINⅠ. In addition, folate, niacin, biotin were more effective on HR-HPV positive women.
