Study on clinical symptoms and influencing factors of influenza-associated severe acute respiratory illness in children younger than 5 years old in Suzhou of China, 2011-2017
10.3760/cma.j.cn112338-20200831-01113
- VernacularTitle:苏州地区2011-2017年5岁以下儿童流感相关严重急性呼吸道感染临床症状和影响因素研究
- Author:
Wanqing ZHANG
1
;
Liling CHEN
;
Fangfang CHENG
;
Zirui DAI
;
Shuang FENG
;
Jun ZHANG
;
Jianmei TIAN
;
Tao ZHANG
;
Genming ZHAO
Author Information
1. 复旦大学公共卫生学院流行病学教研室 公共卫生安全教育部重点实验室，上海 200032
- Keywords:
Children;
Influenza;
Hospitalization;
Influencing factor
- From:
Chinese Journal of Epidemiology
2021;42(6):1044-1049
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the influencing factors of influenza-associated severe acute respiratory illness (SARI) in children younger than 5 years of old in Suzhou, and to provide evidence to support the improvement of prevention and control strategies for influenza in children.Methods:We conducted a prospective influenza surveillance for hospitalized SARI and outpatient influenza-like illness (ILI) at Children′s Hospital of Soochow University from April 2011 to March 2017. We compared the clinical and other characteristics of influenza-positive patients with SARI to those with ILI to find the differences and to identify influencing factors of influenza-associated SARI, using χ2 test and unconditional logistic regression. Results:We found 786 cases of influenza-associated ILI and 413 cases of influenza-associated SARI during the study period. Cough, runny nose, shortness of breath, asthma or wheezing were more common in influenza-associated SARI than in influenza-associated ILI ( P<0.01). Univariate and multivariate logistic regression showed that the influencing factors which significantly associated with increased risk of influenza-associated SARI were as follows: younger age (<6 months OR=3.6, 6-23 months a OR=2.5), respiratory infection history within 3 months (a OR=4.5), chronic lung disease history ( OR=3.4), fever above 39.0 ℃ (39.0-39.9 ℃ a OR=2.4, ≥40.0 ℃ a OR=6.0), and the presence of A/H1N1 (a OR=2.3), A/H3N2 (a OR=1.9). Conclusion:Children younger than 2 years old, with a history of chronic lung disease, a history of respiratory infection within 3 months, or with a fever peak above 39.0 ℃ should seek medical advice as soon as possible or receive annual influenza vaccination to reduce the incidence of influenza-associated serious outcomes.
