Association of lipoprotein a in early pregnancy with gestational diabetes mellitus: a prospective cohort study
10.3760/cma.j.cn112338-20200804-01015
- VernacularTitle:孕早期脂蛋白a水平与妊娠期糖尿病的前瞻性队列研究
- Author:
Xiaotian CHEN
1
;
Ying YE
;
Yi ZHANG
;
Yuan JIANG
;
Yin WANG
;
Hongyan CHEN
;
Yalan DOU
;
Mengru LI
;
Xupeng SUN
;
Weili YAN
Author Information
1. 复旦大学附属儿科医院临床流行病学研究室，上海 201102
- Keywords:
Gestational diabetes mellitus;
Lipoprotein a;
Early pregnancy;
Cohort study
- From:
Chinese Journal of Epidemiology
2021;42(5):903-908
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association of lipoprotein a (Lpa) in early pregnancy with gestational diabetes mellitus (GDM) risk.Methods:A total of 445 pregnant women in 12-14 gestational weeks from "Maternal Key Nutritional Factors and Offspring's Atopic Dermatitis" cohort were included in this study. The demographic characteristics of participants were collected by using questionnaires, and the fasting glucose and lipids levels in early pregnancy were measured. The results of oral glucose tolerance test (OGTT) between 24-28 gestational weeks were recorded. Multivariate logistic regression model was applied to analyze the association of Lpa with GDM by calculating the OR and 95% CI after adjustment for covariates. Results:The incidence number of GDM was 78 (17.5%). The Lpa level in pregnant women with GDM was significantly higher than that in pregnant women without GDM [105.5 (92.0, 122.0) vs. 97.0 (87.0, 109.0) mg/L], P<0.05. Lpa was significantly associated with GDM risk [ OR (95% CI) =1.21(1.08-1.36) per 10 mg/L], P<0.05. The association was still significant after adjustment for covariates including age, gestational weeks et al, the adjusted OR was 1.14 (95% CI: 1.01-1.30), P=0.03. Conclusions:The elevation of Lpa in early pregnancy is one of risk factor for GDM. Maintaining normal Lpa level during early pregnancy can benefit early prevention of GDM and offspring health.
