Plasma cytomegalovirus viremia prevalence among HIV-infected individuals: a Meta-analysis
10.3760/cma.j.cn112338-20200629-00899
- VernacularTitle:HIV感染者巨细胞病毒血症现患率Meta分析
- Author:
Shijie QIAO
1
;
Xing LIU
;
Na HE
Author Information
1. 复旦大学公共卫生学院流行病学教研室，公共卫生安全教育部重点实验室，上海 200032
- Keywords:
HIV;
Cytomegalovirus viremia;
Prevalence;
Meta-analysis
- From:
Chinese Journal of Epidemiology
2021;42(4):723-727
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To understand the prevalence and correlates of plasma cytomegalovirus (CMV) viremia among HIV-infected individuals by Meta-analysis.Methods:A systematic literature retrieval was conducted by PubMed, CNKI, Wanfang, and VIP databases for the information about the prevalence of plasma CMV viremia among HIV-infected individuals published from 2011 to 2020. Meta-analysis was used to calculate the pooled prevalence after literature screening and data extraction.Results:Fifteen studies were included, and the total sample size was 5 076. The random effect model showed that the pooled prevalence of CMV viremia among HIV-infected individuals was 26.2% (95% CI: 16.8%-35.6%, I2=99%); Subgroup analysis and Meta-regression showed that the sources of heterogeneity among different studies were: the proportion of individuals aged >30 years in sample, the proportion of homosexual transmission in the sample, the proportion of individuals whose HIV viral load > 10 4 copies/ml, the proportion of individuals whose CD4 +T lymphocyte counts <200 cells/μl. Conclusion:Among HIV-infected individuals, the prevalence of CMV viremia was high and might be associated with age, HIV transmission mode, the status of HIV/AIDS.
