Relationship of body mass index and blood pressure with diabetes: a nested case-control study
10.3760/cma.j.cn112338-20200401-00493
- VernacularTitle:体质指数、血压与糖尿病发病关系的巢式病例对照研究
- Author:
Rui ZHANG
1
;
Desheng ZHANG
;
Ruonan WANG
;
Chun YIN
;
Zhao BAI
;
Wenya HUANG
;
Jingli YANG
;
Peiyao HUANG
;
Nian LIU
;
Xiaoliang CHEN
;
Yufeng WANG
;
Ning CHENG
;
Yana BAI
Author Information
1. 兰州大学公共卫生学院流行病与卫生统计学研究所 730000
- Keywords:
Diabetes;
Body mass index;
Blood pressure;
Jinchang cohort
- From:
Chinese Journal of Epidemiology
2021;42(4):662-667
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship of body mass index and blood pressure with the incidence of diabetes in Jinchang cohort.Methods:We designed a nested case-control study, a total of 29 572 workers who had no history of diabetes in baseline survey in Jinchang cohort were selected as the study cohort from June 2011 to December 2013. After 2 year follow-up, 1 021 workers with first diagnosed diabetes were selected as the case group, after 1∶1 matching according to the same gender and age ±2 years among those without diabetes, circulatory system, or endocrine system diseases during the same follow-up period, 1 021 controls was selected and 2 042 subjects were finally included. We used multivariate conditional logistic regression model, additive interaction model and multiplicative interaction model to explore the relationship of body mass index and blood pressure with the incidence of diabetes.Results:After adjusting for factors such as occupation, alcohol use, family history of diabetes, hyperuricemia, hypercholesterolemia, hypertriglyceridemia, low-HDL cholesterolemia and high-LDL cholesterolemia, multivariate conditional logistic regression analysis showed that the risk of diabetes increased with body mass index and blood pressure. Hypertension and overweight/obesity had a multiplicative interaction on the incidence of diabetes. The risks of diabetes in men and women with hypertension and overweight/obese were 2.04 times (95% CI: 1.54-2.69) and 3.88 times (95% CI: 2.55-5.91) higher than those in men and women with normal body weight and blood pressure, respectively. In the combination of BMI and blood pressure, obese individuals with SBP≥160 mmHg were 4.57 times (95% CI: 2.50-8.34) more likely to have diabetes than those with normal BMI and SBP, obese individuals with DBP≥90 mmHg were 3.40 times (95% CI: 2.19-5.28) more likely to have diabetes than those with normal BMI and DBP. Conclusions:Overweight/obesity and hypertension can increase the risk of diabetes. Health education about body weight and blood pressure controls should be strengthened to reduce the risk of diabetes.
