A sub-cohort study design of the maternal and infant microbes in China National Birth Cohort
10.3760/cma.j.cn112338-20201211-01406
- VernacularTitle:中国国家出生队列母婴肠道微生物亚队列研究
- Author:
Yuan LIN
1
;
Qun LU
;
Yangqian JIANG
;
Qingxia MENG
;
Xiaoyan WANG
;
Cong LIU
;
Yuanlin HE
;
Xiumei HAN
;
Kun ZHOU
;
Jiangbo DU
;
Hongxia MA
;
Guangfu JIN
;
Hong LI
;
Xiufeng LING
;
Hongbing SHEN
;
Zhibin HU
Author Information
1. 南京医科大学公共卫生学院儿少卫生与妇幼保健学系 211166
- Keywords:
Mother and child;
Gut microbiome;
Birth cohort
- From:
Chinese Journal of Epidemiology
2021;42(4):597-601
- CountryChina
- Language:Chinese
-
Abstract:
The importance of gut microbes to human health has gradually attracted attention. With the use of animal models, it has been revealed that maternal microbes during pregnancy could influence their children's health outcomes through shaping their microbial composition and regulating the development of their metabolic and immune system. However, the physiological mechanism of the human body is more complex and is affected by the interaction of multiple factors. The research results obtained from animal models are often inconsistent with human studies. At present, the influence of maternal intestinal microbes during pregnancy on the microbial colonization in their offspring and on a series of children's health outcomes is still unclear. Establishing a sub-cohort to detect the microbiome of the women across pregnancy and of their offspring, and further to integrate with variety of environmental and behavioral exposures can better provide reliable support for the research on the mechanism of children's health and diseases. This paper briefly introduces the research objectives, content, progress, strength and limitations of the sub-cohort study.
