Analysis on serotype and antimicrobial resistance of invasive non-typhoidal Salmonella
10.3760/cma.j.cn112338-20200316-00361
- VernacularTitle:侵袭性非伤寒沙门菌血清型和耐药性分析
- Author:
Yujie HU
1
;
Xuebin XU
;
Yan WANG
;
Wei WANG
;
Xinnan CUI
;
Qiongyu HE
;
Menghan LI
;
Jin XU
;
Fengqin LI
Author Information
1. 国家食品安全风险评估中心国家卫生健康委员会食品安全风险评估重点实验室，北京100021
- Keywords:
Invasive non-typhoidal Salmonella;
Serotype;
Antimicrobial resistance
- From:
Chinese Journal of Epidemiology
2021;42(3):549-554
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the serotypes and antimicrobial resistance of seven invasive non-typhoidal Salmonella (iNTS) isolates. Methods:For 7 iNTS strains collected, serotype identification, antimicrobial susceptibility testing and whole genome sequencing were performed. We identified, annotated and analyzed the serotypes, MLST types, and antimicrobial resistance genes.Results:Among the 7 tested iNTS isolates, we found one Salmonella Typhimurium strain and two Salmonella Ⅰ 4, [5], 12: i:- strains whose MLST types were ST34, two Salmonella Enteritidis strains, one Salmonella Corvallis strain and one strain of unknown serotype with the antigenic formulae of Ⅰ 4, [5], 12: d:- (ST279 type). Six of seven strains were monophasic and the deletion or pseudogenization of Salmonella Flagellum gene might contribute to the enhancement of Salmonella invasiveness. None was found to be resistant to tigarcycline, aztreonam, amikacin, cephalosporins and carbapenem and one Salmonella Typhimurium strain was found to be co-resistant to eight classes of antimicrobials at the same time. Resistance genes were generally in accord with relative resistant phenotypes. Conclusion:The iNTS strains could show high level multi-drug resistance, indicating that close attention should be paid to the resistance of iNTS though the overall resistance might be relatively not high.
