Association between hyperuricemia and incidence risk for cardiometabolic abnormity in children
10.3760/cma.j.cn112338-20200825-01094
- VernacularTitle:儿童高尿酸血症与心血管代谢异常发生风险
- Author:
Peiyu YE
1
;
Xiaoyuan ZHAO
;
Yinkun YAN
;
Pei XIAO
;
Dongqing HOU
;
Zhongxin ZHU
;
Zhaocang YU
;
Hongjian WANG
;
Aiyu GAO
;
Hong CHENG
;
Jie MI
Author Information
1. 国家儿童医学中心儿童慢病管理中心，首都医科大学附属北京儿童医院，北京 100045
- Keywords:
Children;
Hyperuricemia;
Cardiometabolic abnormity;
Cohort study
- From:
Chinese Journal of Epidemiology
2021;42(3):433-439
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationships between hyperuricemia and the incidence risk for cardiometabolic abnormity in children.Methods:Data were obtained from School-based Cardiovascular and Bone Health Promotion Program. In 2017, a total of 15 391 children aged 6-16 years in Beijing were selected through stratified cluster sampling at baseline survey. Follow-up investigation was conducted in 2019. Logistic regression model was used to analyze the relationships of uric acid quartiles and change in uric acid levels with incidence risks for cardiometabolic abnormity (hypertension, hyperglycemia and dyslipidemia).Results:A total of 8 807 children (4 376 boys, 4 431 girls) were included in the analysis, the average age of the children was (11.1±3.3) years at baseline survey. The adjusted odds ratios ( ORs) and 95% confidence intervals ( CIs) of incidence risk for hypertension in the third and fourth quartiles of the UA were 1.39 (1.11-1.75) and 1.56 (1.19-1.81), respectively. The ORs and 95% CIs of risk for high LDL-C in the second, third and fourth quartiles were 1.88 (1.16-3.05),1.98 (1.23-3.17) and 2.25 (1.42-3.57). The uric acid level increased by one standard deviation, the risk increased by 17% for hypertension and 27% for high LDL-C. The uric acid level increased by 10 μmol/L, the risk increased by 2.1% for hypertension and 2.9% for high LDL-C. The gender-stratified analysis showed that the similar results. The ORs and 95% CIs were 1.32 (1.09-1.60) and 1.50 (1.05-2.16) for hypertension, 1.90 (1.38-2.60) and 2.96 (1.58-5.52) for high TC, 1.78 (1.26-2.51) and 2.84 (1.60-5.03) for high LDL-C in the groups of newly diagnosed hyperuricemia and persistent hyperuricemia. Conclusions:Higher uric acid level was associated with increased incidence risks for hypertension, abnormal TC and LDL-C. Maintaining optimal uric acid level by children might contribute to the early prevention of cardiovascular diseases.
