Prevalence and correlates of plasma cytomegalovirus viremia among newly reported HIV/AIDS patients in Taizhou city, 2017-2018
10.3760/cma.j.cn112338-20200420-00601
- VernacularTitle:台州市2017-2018年新报告HIV/AIDS巨细胞病毒血症现患率及影响因素研究
- Author:
Shijie QIAO
1
;
Sujuan ZHOU
;
Lulu XU
;
Xiaoxiao CHEN
;
Yuanyuan XU
;
Weiwei SHEN
;
Xing LIU
;
Haijiang LIN
;
Na HE
Author Information
1. 复旦大学公共卫生学院流行病学教研室，公共卫生安全教育部重点实验室，上海200032
- Keywords:
HIV/AIDS;
Cytomegalovirus;
Viremia;
Prevalence;
Related factors
- From:
Chinese Journal of Epidemiology
2021;42(2):316-320
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the prevalence and correlates of plasma cytomegalovirus (CMV) viremia among newly reported antiretroviral therapy (ART)-naive HIV/AIDS patients in Taizhou during 2017-2018.Methods:CMV DNA was measured in plasma specimens of newly reported ART-naive HIV/AIDS patients by quantitative PCR. Both univariable and multivariable logistic regression analyses were carried out to evaluate CMV viremia correlations among the individuals.Results:Of 612 HIV/AIDS patients, 480 (78.4%) were male, 125 (20.4%) were over 60 years old, 177 (28.9%) were infected via homosexual transmission, and 430 (70.3%) via heterosexual transmission. The prevalence of CMV viremia among HIV/AIDS patients was 13.4% (82/612). Multivariable logistic regression analysis showed that the risk of CMV viremia in CD 4+ lymphocyte cells counts (CD 4+) ≤200 cells/μl group was higher than CD 4 counts >500 cells/μl ( OR=5.10, 95% CI:1.74-14.96, P=0.003); The median CMV DNA level (log 10) of 82 viremic patients was 1.57 ( P 25, P 75:1.04,2.13); Viremic patients with CD 4 counts ≤200 cells/μl had the highest CMV viral load ( P<0.01). Conclusions:Among ART-naive HIV/AIDS patients, the prevalence of CMV viremia was significantly associated with immunodeficiency status. Further research is needed to evaluate the association between CMV viremia and the course of HIV infection.
