Association between apolipoprotein E-containing HDL-C and coronary heart disease risk: a community-based cohort study
10.3760/cma.j.cn112338-20200310-00302
- VernacularTitle:携带载脂蛋白E的HDL-C与冠心病发病风险的前瞻性队列研究
- Author:
Yue QI
1
;
Jing LIU
;
Miao WANG
;
Jiayi SUN
;
Jun LIU
;
Qiuju DENG
;
Dong ZHAO
Author Information
1. 首都医科大学附属北京安贞医院，北京市心肺血管疾病研究所流行病研究室 100029
- Keywords:
Apolipoprotein E-containing HDL-C;
Coronary heart disease;
Incident risk
- From:
Chinese Journal of Epidemiology
2021;42(2):297-302
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To assess whether apolipoprotein E-containing HDL-C (APOE-HDL-C) is causally associated with coronary heart disease (CHD) risk.Methods:In total, 5 417 cardiovascular disease-free participants at baseline were followed up for up to 10 years in the Chinese Multi-provincial Cohort Study. APOE-HDL-C and HDL-C were measured in all participants. APOE-HDL-C/total HDL-C ratio was calculated. Multivariate Cox regression was employed to assess the association between HDL-C related biomarkers and 10-year CHD incident risk.Results:A total of 100 incident CHD events occurred during a mean 6.8 years follow-up. High levels of baseline HDL-C related biomarkers were significantly negatively associated with incident CHD risk. Comparison with participant with lowest level of APOE-HDL-C/total HDL-C ratio, those with highest level of APOE-HDL-C/total HDL-C ratio had 74% decreased risk of CHD ( HR=0.26, 95% CI: 0.12-0.71). The individual with the highest level of APOE-HDL-C/total HDL-C ratio had the lowest absolute risk[0.48% (0.44%-0.52%)] of CHD, which was significantly lower than that [0.83% (0.78%-0.88%)] of the individual with the highest level of HDL-C. Conclusions:Our findings revealed that the APOE-HDL-C/total HDL-C ratio was significantly related to a 10-year increased risk of incident CHD, even beyond HDL-C. It seemed that APOE-HDL-C could serve as a new indicator of the anti-atherosclerotic function of HDL.
