Molecular mechanism and research progress of hepatocellular carcinoma induced by hepatitis B virus mutation
10.3760/cma.j.cn112338-20200923-01178
- VernacularTitle:乙型肝炎病毒变异诱发肝细胞癌的分子机制及其研究进展
- Author:
Zishuai LI
1
;
Guangwen CAO
Author Information
1. 海军军医大学海医系流行病学教研室，上海 200433
- Keywords:
Hepatocellular carcinoma;
Hepatitis B virus;
Inflammation;
Evolution;
Development
- From:
Chinese Journal of Epidemiology
2021;42(1):15-21
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma (HCC) caused by hepatitis B virus (HBV) is the first cause of cancer-caused death in China. This study, from the perspective of HBV genomic epidemiology, systematically investigated the evolution of HBV and their interaction with host genetic factors in each stage of HBV carcinogenesis and comprehensively analyzed the role of apolipoprotein B mRNA editing enzyme catalytic polypeptides (APOBEC) family in the inflammation-to-cancer transformation. Based on our findings and related studies, we proposed "cancer evolution and development" (Cancer Evo-Dev) theoretical system suitable for most cancer types. Cancer Evo-Dev lays a theoretical foundation for understanding the mechanism of inflammation to promote the development of cancer, which is of great significance for the specific prevention, prediction, early diagnosis, and targeted therapy of malignant diseases.
