Influencing factors of antiretroviral therapy and its association with immunological effect among HIV/AIDS patients in Taizhou city, 2006-2019
10.3760/cma.j.cn112338-20200611-00833
- VernacularTitle:台州市2006-2019年HIV/AIDS抗病毒治疗策略与免疫学效果的关联及影响因素分析
- Author:
Jiayu HE
1
;
Shanling WANG
;
Yuanyuan XU
;
Weiwei SHEN
;
Yingying DING
;
Haijiang LIN
;
Na HE
;
Xiaoxiao CHEN
Author Information
1. 复旦大学公共卫生学院流行病学教研室，公共卫生安全教育部重点实验室，上海 200032
- Keywords:
HIV/AIDS;
Antiretroviral therapy;
Strategy;
Immunological effect;
Influencing factors
- From:
Chinese Journal of Epidemiology
2020;41(12):2093-2097
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze influencing factors of instant antiretroviral therapy (ART) and explore associution between strategies of ART and immunological effects among HIV/AIDS patients in Taizhou city during 2006-2019.Methods:A retrospective cohort study was conducted on HIV/AIDS patients under ART, and a logistic regression model was used to analyze factors of instant ART. The student t-test and chi-square test were used to compare immunological effect of different ART strategies while the Kaplan-Meier method was used to generate a survival curve. Results:A total of 2 971 HIV/AIDS patients were enrolled with 1 786 cases (60.1%) having instant ART strategy. The proportion of instant ART were 77.8% (1 170/1 504) during 2016 to 2019. The treatment success rate of the instant ART group (87.4%, 1 561/1 786) were higher than the delayed ART group (84.4%, 1 000/1 185). The results of multivariate logistic regression model indicated that male (a OR=1.28, 95 %CI: 1.03-1.59), married (a OR=1.71, 95 %CI: 1.33-2.19) and baseline CD 4+T lymphocyte cells (CD 4) counts ≤200 cells/μl (a OR=1.60, 95 %CI: 1.27-2.02) were factors positively related to instant ART while 31-40 years old (a OR=0.63, 95 %CI: 0.48-0.84), infected through heterosexual transmission(a OR=0.60, 95 %CI: 0.49-0.74) and diagnosed before 2015 (a OR=0.20, 95 %CI: 0.17-0.23) were inversely related to instant ART. The increase of the CD 4/CD 8 ratio was greater, and the cumulative ART success rate was higher each year in the instant ART group than in the delayed ART group ( P<0.05). Conclusions:The instant ART strategy has been well implemented in Taizhou city during 2006-2019, and the immunological effect was better in instant ART group. The proportion of instant ART were more than 60.0% among HIV/AIDS patients. Instant ART strategy needs to be strengthened for those who are 31-40 years old, women, unmarried, and infected through heterosexual transmission in an attempt to further increase treatment level and improve treatment effect.
