Results and cost-effectiveness of colorectal cancer screening program among urban residents in Zhejiang province, 2013-2018
10.3760/cma.j.cn112338-20200324-00424
- VernacularTitle:浙江省2013-2018年城市居民结直肠癌筛查结果及成本效果分析
- Author:
Le WANG
1
;
Huizhang LI
;
Chen ZHU
;
Youqing WANG
;
Huijuan ZHOU
;
Xiaohua SUN
;
Meizhen ZHANG
;
Lie JIN
;
Lingbin DU
Author Information
1. 中国科学院大学附属肿瘤医院（浙江省肿瘤医院）防治科/中国科学院基础医学与肿瘤研究所，杭州 310022
- Keywords:
Colorectal neoplasm;
Screening;
Compliance;
Detection rate;
Cost-effectiveness
- From:
Chinese Journal of Epidemiology
2020;41(12):2080-2086
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the results and cost-effectiveness of colorectal cancer (CRC) screening program among Zhejiang urban residents so as to provide evidence for further optimization of CRC screening strategies.Methods:Based on the Cancer Screening Program in Urban China which was conducted in Zhejiang province from 2013-2018, data related to the rates on compliance and detection through the CRC screening program among the 40-74 year-old residents were analyzed. Chi-square tests were used to compare the differences among groups, and multivariate logistic regression models were applied to explore the potential risk factors. Cost-effectiveness ratio (CER) was calculated by using the cost per lesion detected as the indicator.Results:Among all the 166 285 participants who completed the risk assessment questionnaire, 21 975 (13.2%) were recognized as under the high risk of CRC and 4 389 (20.0%) of them received the colonoscopy. The detection rates of CRC, advanced adenoma, and non-advance adenoma were 0.3% (11 cases), 2.7% (119 cases), and 5.2% (229 cases), respectively. Results from the multivariate logistic regression analyses showed that factors as age, gender, education level, smoking, drinking alcohol, previous fecal occult blood test (FOBT), polyp history, and family history of CRC were significantly associated with the compliance rate of colonoscopy while age, smoking and polyp history were significantly associated with the detection rate of advanced neoplasms (CRC and advanced adenoma). The costs were ￥22 355.74 Yuan for every CER advanced neoplasm detection and ￥264 204.18 Yuan per CRC detection, respectively. The CER decreased along with ageing. Sensitivity analysis showed that CERs were expected to decrease when the compliance rate of colonoscopy was increasing.Conclusions:The current screening program seems effective in detecting the precancerous colorectal lesions, but the relatively low compliance rate of colonoscopy restricting both the diagnostic yields and economic benefits. It is necessary to improve the awareness and acceptance of colonoscopy among the high-risk CRC population.
