Meta-analysis on association between TNF-α and CCR5Δ32 gene polymorphisms and influenza A(H1N1)pdm09
10.3760/cma.j.cn112338-20200209-00082
- VernacularTitle:TNF-α及CCR5Δ32基因多态性与A（H1N1）pdm09相关性的Meta分析
- Author:
Tao CHEN
1
;
Meng XIAO
;
Kun CHU
;
Xiaojun TANG
;
Jing YANG
;
Yuelong SHU
Author Information
1. 中国疾病预防控制中心病毒病预防控制所国家流感中心，世界卫生组织流感参比和研究合作中心，北京 102206
- Keywords:
TNF-α;
CCR;
Gene polymorphism;
Influenza
- From:
Chinese Journal of Epidemiology
2020;41(11):1909-1914
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the associations between TNF-α and CCR5Δ32 gene polymorphisms and influenza A(H1N1)pdm09.Methods:Studies in PubMed, Cochrane Library, OVID, EBSCO, Web of Science published before February 7, 2019 were retrieved comprehensively. Observational studies related to TNF-alpha and CCR5 gene polymorphisms and influenza A(H1N1) pdm09 were collected. A strict quality evaluation was carried out according to NOS scale. Meta-analysis was performed using software Revman 5.0 and Stata 11.0.Results:After screening, a total of 8 studies were included in this Meta-analysis. The results showed that TNF-α gene polymorphism rs361525 might be associated with the risk of influenza A(H1N1)pdm09 virus infection (A vs. G: OR=2.25, 95 %CI: 1.09-4.65, P=0.03; AA vs. GG: OR=4.34, 95 %CI: 1.65-11.41, P=0.003; AA vs. AG+GG: OR=4.38, 95 %CI: 1.67-11.48, P=0.003), similar trend also found in rs1800750 (AA+AG vs. GG: OR=2.42, 95 %CI: 1.24-4.71, P=0.01). The results of subgroup analysis indicated that A allele and AA+AG genotypes of rs361525 were risk factors for influenza A(H1N1) pdm09 virus infection in Caucasians. AA genotype was a risk factor for influenza A(H1N1) pdm09 virus infection in Mexican ( P<0.05). There was no significant difference in the genetic polymorphism of CCR5 and the severity of influenza A (H1N1) pdm09 virus indection ( P>0.05). Conclusion:People with allele A or genotype AA at rs361525, genotype AA+AG at rs1800750 of TNF-α gene might be more susceptible to influenza A(H1N1) pdm09.
