Progress in research of Fusobacterium nucleatum and upper gastrointestinal cancer
10.3760/cma.j.cn112338-20191102-00776
- VernacularTitle:具核梭杆菌与上消化道癌研究进展
- Author:
Minjuan LI
1
;
Dantong SHAO
;
Ru CHEN
;
Shaoming WANG
;
Wenqiang WEI
Author Information
1. 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院肿瘤登记办公室，北京 100021
- Keywords:
Fusobacterium nucleatum;
Upper gastrointestinal cancer;
Precancerous lesions
- From:
Chinese Journal of Epidemiology
2020;41(11):1938-1941
- CountryChina
- Language:Chinese
-
Abstract:
With the development of multi-omics and high throughput sequencing technology, studies have shown that the disorder of microbiota is related to various cancers. Nevertheless, the research on the relationship between upper digestive tract cancer or precancerous lesions and gastrointestinal microecology is still less. Fusobacterium nucleatum, one of the oral symbiotic bacteria, is also an opportunistic pathogen, which can promote the formation of tumor microenvironment and can be used as a new biomarker for the early detection and early diagnosis of cancer. In this study, by searching CNKI, Wanfang data, PubMed and Embase databases, it was found that the abundance of F. nucleatum in cancer tissues is higher than that in paracancerous tissues and associated with poor prognosis. The research of relationship between F. nucleatum and precancerous lesions needs to be carried out urgently. In addition, the types of specimens, sequencing technology, strain subtypes, carcinogenic mechanism and other directions still need to be explored.
