Association between lifestyle-related factors and colorectal adenoma
10.3760/cma.j.cn112338-20200414-00572
- VernacularTitle:基于人群筛查的生活方式相关因素与结直肠腺瘤的关系研究
- Author:
Liuqing YOU
1
;
Kai GAO
;
Qilong LI
;
Jinhua YANG
;
Jiayu LI
;
Xiaocong ZHANG
;
Mengling TANG
;
Jianbing WANG
;
Kun CHEN
;
Mingjuan JIN
Author Information
1. 浙江大学公共卫生学院流行病与卫生统计学系，杭州 310058
- Keywords:
Colorectal adenoma;
Lifestyle-related factor;
Aspirin
- From:
Chinese Journal of Epidemiology
2020;41(10):1649-1654
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association between lifestyle-related factors and colorectal adenoma.Methods:Based on the Screening Project of Early Diagnosis and Treatment of Colorectal Cancer in Jiashan county Zhejiang province, from August 2012 to March 2018, information gathered through records on questionnaire and colonoscopic diagnosis were collected from participants with positive results during the primary screening stage. According to the findings of colonoscopy, 11 232 controls without any colorectal diseases and 3 895 cases with colorectal adenoma were included in the study. Multivariate logistic regression models were used to analyze the association between lifestyle-related factors and colorectal adenoma.Results:After adjusting for possible confounding factors, results from multivariate logistic regression analysis showed that smoking, alcohol drinking and obesity were positively related to the risk of colorectal adenoma, with ORs (95 %CIs) as 1.38 (1.24-1.54), 1.37 (1.24-1.51) and 1.38 (1.20-1.59) respectively. However, regular aspirin intake was negatively related with the risk of colorectal adenoma ( OR=0.65, 95 %CI: 0.53-0.80). After stratified by sex and age, data showed that the associations between smoking, alcohol drinking and colorectal adenoma were statistically significant in males, and the association between regular aspirin intake and colorectal adenoma was also statistically significant in older participants (aged 60 years and older). Conclusion:Smoking, alcohol drinking, regular aspirin intake and obesity were associated with colorectal adenoma.
