Association between obesity and risk for colorectal advanced adenoma
10.3760/cma.j.cn112338-20200410-00553
- VernacularTitle:肥胖与大肠高风险腺瘤发病风险研究
- Author:
Jie SHEN
1
;
Miao MO
;
Weixing DAI
;
Changming ZHOU
;
Zezhou WANG
;
Guoxiang CAI
;
Lianfang ZHAI
;
Ye XU
;
Ying ZHENG
Author Information
1. 复旦大学附属肿瘤医院肿瘤预防部，上海 200032；复旦大学上海医学院肿瘤学系，上海 200032
- Keywords:
Colorectal neoplasm;
Obesity;
Colorectal advanced adenoma
- From:
Chinese Journal of Epidemiology
2020;41(10):1643-1648
- CountryChina
- Language:Chinese
-
Abstract:
Objectives:To understand the association between obesity and the risk for colorectal advanced adenoma.Methods:Community residents aged 45 to 74 who had participated in the Shanghai community-based colorectal cancer (CRC) screening project in 2008 were included in our study. Anthropometries information including body weight, height and risk factors for colorectal advanced adenoma were collected. Results on colonoscopic diagnosis and personal health records were used for supplementary outcome information retrieval. Multivariate Cox proportional hazard regression models were used to evaluate the hazard ratio ( HR) and 95 %CI of obesity on the risk for colorectal advanced adenoma. Results:20 811 residents were followed up for 122 739.36 person-years, with a median follow-up time of 5.87 years. A total of 657 cases of advanced adenomas were identified. After adjusting for potential confounding risk factors such as age, sex, family history of CRC, level of education, marriage, cigarette smoking, alcohol drinking, foods intake including fat, fried or pickled, vegetables and fruits etc., the HR was 1.25 (95 %CI: 1.04-1.51) for obese people when compared with the normal weight persons. Further stratified analysis by age, gender and family history of CRC, results showed that obese people had a much higher risk of colorectal advanced adenoma than those with normal weight (male: HR=1.57, 95 %CI: 1.20-2.04; more than 60- year-old: HR=1.63, 95 %CI: 1.23-2.16). Conclusion:Data from this large scale population-based study revealed that obesity might be an independent risk factor for colorectal advanced adenoma and the risk increases along with the increase of BMI in China.
