Seroprevalence of parvovirus B19 in pregnant women in Korea: A study of sociodemographic and medical risk factors.
- Author:
Ji Hoon YOO
1
;
Jeong Jae LEE
;
Jeong Bum CHOI
;
Shin Hye KIM
;
Kyu Yeon CHOI
;
Mi Kyung KIM
;
Eun Hee PARK
;
Jong Su KIM
;
Hwan Sung JOE
;
Tae Hui KIM
;
Im Soon LEE
;
Gwon Hae LEE
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Soonchunhyang University, Seoul, Korea. jjlee@hosp.sch.ac.kr
- Publication Type:Original Article
- Keywords:
Parvovirus B19 IgG;
Parvovirus B19 IgM;
Seroprevalence;
Hydrops fetalis;
Stillbirth
- MeSH:
Abortion, Spontaneous;
Adult;
Antibodies;
Asian Continental Ancestry Group;
Chungcheongnam-do;
Enzyme-Linked Immunosorbent Assay;
Female;
Gestational Age;
Gyeonggi-do;
Gyeongsangbuk-do;
Humans;
Hydrops Fetalis;
Immunoglobulin G;
Immunoglobulin M;
Korea*;
Maternal Age;
Parity;
Parvovirus B19, Human;
Parvovirus*;
Pregnancy;
Pregnancy Trimester, Second;
Pregnant Women*;
Prevalence;
Prospective Studies;
Risk Factors*;
Seoul;
Seroepidemiologic Studies*;
Stillbirth
- From:Korean Journal of Obstetrics and Gynecology
2006;49(12):2535-2542
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: The prevalence of Parvovirus B19 antibody in Korea has not been known. The aim of this study is to analyze variation of prevalence according to area, job and maternal age. METHODS: A prospective study of the pregnant women was performed at first & second trimester. This study was an analysis of 221 pregnant women who lived in Seoul, Bucheon, Cheonan, and Gumi in South Korea. All serum samples were drawn during first and second trimester. Presence of parvovirus B19 IgG antibodies and IgM antibodies was determined by ELISA using Parvovirus B19 IgM-3rd Generation EIA, Parvovirus B19 IgG-3rd Generation EIA, Parvovirus B19 Quantitative IgG Calibrators Kit (Biotrin International, Ireland). Data and level of significance were analysed by chi-square test using the SPSS program. RESULTS: In total, 118 (53.3%) of the 221 pregnant women were IgG antibody positive for parvovirus B19 during first and second trimester. Only 1 (0.5%) of 221 pregnant women was IgM antibody positive. There were no nonimmune fetal hydrops, spontaneous abortion and stillbirth in acutely infected woman. There were no statistically significant differences in Parvovirus IgG positive rate according to maternal age, area, parity and gestational age. CONCLUSION: This study has confirmed seroprevalence rate of human parvovirus B19 in South Korea comparable to the rate found in Asian countries. But positive rate of Parvovirus IgG was higher than other Asian countries. This study also showed that a proportion of adults of childbearing age was still susceptible to the virus and serological data also showed evidence of infection occurring in this age group. It will be of interest for the obstetricians in this country to note the role of Parvovirus B19 in relation to the extent of stillbirths and hydrops fetalis and to if there is any need for a vaccine to reduce fetal wastage.
