Progress in research of influencing factors of oral microbiome and association between oral microbiome and upper gastrointestinal cancer
10.3760/cma.j.cn112338-20190725-00549
- VernacularTitle:口腔菌群影响因素及其与上消化道肿瘤关联研究进展
- Author:
Dantong SHAO
1
;
Minjuan LI
;
Ru CHEN
;
Wenqiang WEI
Author Information
1. 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院，北京 100021
- Keywords:
Oral microbiome;
Upper gastrointestinal cancer;
Influence factor;
Tumor biomarker
- From:
Chinese Journal of Epidemiology
2020;41(7):1160-1164
- CountryChina
- Language:Chinese
-
Abstract:
The composition of human oral microorganism is numerous and complex and is easily affected by many factors. With the development of metagenomic technology, the important role of oral microbiome in the development of tumor has attracted extensive attention. A literature retrieval was conducted through PubMed, Embase, CNKI and WanFang database for an analysis on the characteristics of oral bacteria and its association with oral cancer, esophageal cancer and gastric cancer. The results indicated that oral microbiome can be influenced by age, gender, race, and lifestyle. Specific oral bacteria were associated with high risk of upper gastrointestinal cancer, indicating a potential role of oral microbiota to be the biomarker for upper gastrointestinal cancer. This paper summarizes the progress in the research of the association between oral microbiome and upper gastrointestinal cancer, showing a new direction for the exploration of microbiological etiology of upper gastrointestinal cancer and providing scientific evidence for the optimization of early detection and treatment of upper gastrointestinal cancer.
