Study on the correlation between prognosis of patients with chronic hepatitis B under interferon treatment and polymorphism of both calcitonin gene related peptide and receptor activity modifying protein 1
10.3760/cma.j.cn112338-20190722-00540
- VernacularTitle:干扰素治疗慢性乙型肝炎预后与降钙素基因相关肽及受体活性蛋白1基因多态性的关联研究
- Author:
Li ZHANG
1
;
Lin ZHOU
;
Xia GAO
;
Xuran ZHENG
;
Mengru YANG
;
Ning ZHANG
;
Gang YANG
;
Wenxuan LIU
Author Information
1. 河北医科大学公共卫生学院预防医学系2015级，石家庄 050017
- Keywords:
Chronic hepatitis B;
Interferon therapy;
Calcitonin gene related peptide;
Receptor activity modifying protein 1;
Single nucleotide polymorphism
- From:
Chinese Journal of Epidemiology
2020;41(6):924-928
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the association of two single-nucleotide polymorphisms (SNP) [Calcitonin gene related peptide (CGRP) rs155209 and receptor activity modifying protein 1 (RAMP1) rs3754701] and the prognosis of chronic hepatitis B patients who were under interferon therapy.Methods:A total of 317 patients and their anticoagulant blood samples were collected in this study. The SNPs in the CGRP and region RAMP1 were genotyped using matrix-assisted laser desorption/ionization time of flight mass spectrometry. Logistic regression method was used to assess the results from different phenotypic outcomes between cases and controls, after adjusted for sex and age in co-dominant, dominant and recessive genetic models.Results:Data from this study clearly demonstrated the relevance of CGRP rs155209 and RAMP1 rs3754701 with DNA response and ALT response. RAMP1 rs3754701T was strongly associated with both DNA response and ALT response ( OR=2.277, 95 %CI: 1.386-3.741, P=0.001; OR=1.694, 95 %CI: 1.073-2.675, P=0.024). However, CGRP rs155209C was less prone to DNA response and ALT response ( OR=0.150, 95 %CI: 0.083-0.271, P<0.001; OR=0.583, 95 %CI: 0.367-0.925, P=0.022). Conclusions:Results from our study suggested that both RAMP1 rs3754701 and CGRP rs155209 were associated with the prognosis of patients under interferon therapy in Han population, from the northern parts of China while RAMP1 rs3754701T was a protective factor for both ALT response and DNA response, but CGRP rs155209C carriers were less prone to DNA and ALT responses.
