Effects of Rikkunshito (TJ-43) on Esophageal Motor Function and Gastroesophageal Reflux.
- Author:
Terumi MORITA
1
;
Kenji FURUTA
;
Kyoichi ADACHI
;
Shunji OHARA
;
Takashi TANIMURA
;
Kenji KOSHINO
;
Tomochika UEMURA
;
Kohji NAORA
;
Yoshikazu KINOSHITA
Author Information
1. Second Department of Internal Medicine, Shimane University Faculty of Medicine, Izumo-shi, Shimane, Japan. kfuruta@med.shimane-u.ac.jp
- Publication Type:Original Article
- Keywords:
Herbal medicine;
Esophageal pH monitoring;
Esophageal sphincter, lower;
Peristalsis
- MeSH:
Adult;
Contracts;
Cross-Over Studies;
Drugs, Chinese Herbal;
Electric Impedance;
Esophageal pH Monitoring;
Esophageal Sphincter, Lower;
Esophagus;
Gastroesophageal Reflux;
Herbal Medicine;
Humans;
Hydrogen-Ion Concentration;
Male;
Motor Activity;
Peristalsis;
Supine Position
- From:Journal of Neurogastroenterology and Motility
2012;18(2):181-186
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND/AIMS: Rikkunshito (TJ-43), an herbal medicine, has been demonstrated to relieve gastroesophageal reflux symptoms. However, the effects of TJ-43 on esophageal motor functions have not been fully determined. This double-blind crossover study was performed to investigate the effects of TJ-43 on esophageal motor functions and gastroesophageal reflux. METHODS: The subjects were 10 normal male volunteers. Lower esophageal sphincter pressure and esophageal body peristaltic contractions with and without 1-week administration of TJ-43 were examined in a crossover fashion. Post-prandial gastroesophageal reflux was also determined using a multi-channel impedance pH dual monitor. RESULTS: TJ-43 at a standard dose of 7.5 g/day did not significantly augment esophageal peristaltic contraction pressure measured in the proximal, middle and distal segments of the esophagus, whereas increment of resting lower esophageal sphincter pressure was observed in a supine position. In addition, TJ-43 administration did not decrease post-prandial gastroesophageal acid, non-acid reflux events or accelerate esophageal clearance time. CONCLUSIONS: TJ-43 at a standard dose did not have a significant effect on esophageal motor activity or gastroesophageal reflux in healthy adults.
