Burden of disease attributed to high level serum low-density lipoprotein cholesterol in China in 2017
10.3760/cma.j.cn112338-20191205-00861
- VernacularTitle:2017年中国人群高血清低密度脂蛋白胆固醇归因疾病负担研究
- Author:
Xiaohui XU
1
;
Jing YANG
;
Lijun WANG
;
Peng YIN
;
Jiangmei LIU
;
Wenlan DONG
;
Wei WANG
;
Xuan WANG
;
Li QIN
;
Maigeng ZHOU
Author Information
1. 中国疾病预防控制中心慢性非传染性疾病预防控制中心综合防控室，北京 100050
- Keywords:
Low-density lipid cholesterol;
Population attributable fraction;
Mortality;
Disability-adjusted life years
- From:
Chinese Journal of Epidemiology
2020;41(6):839-844
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To quantitatively analyze the death and disability-adjusted life years (DALY) attributed to high level serum LDL-C in Chinese population in 2017.Methods:Data were obtained from the '2017 Global Burden of Disease Study (GBD2017)’. Population attributable fraction (PAF), number and rate of deaths and DALY attributable to high LDL-C were used to describe the burden of disease by gender, age groups, diseases and provinces in China. Both rates on mortality and DALY were standardized by GBD world population.Results:In 2017, 862 759 deaths were caused by high level serum LDL-C in China, that accounting for 8.25 % of the total deaths. Of the attributable deaths, 705 355 (81.76 %) persons died from ischemic heart disease (IHD), while the remaining 18.24 % from ischemic stroke (IS). High LDL-C accounted for 40.30 % of the total deaths from ischemic heart disease and 18.49 % from ischemic stroke. The highest PAF of death (13.70 %) appeared in Jilin province and the lowest in Zhejiang province (4.65 %). PAF of death was seen higher in females than in males, while both age-standardized rates of mortality and DALY appeared higher in males than in females. High LDL-C attributed mortality rate appeared as 61.08/100 000 after standardization in Chinese population. High LDL-C attributed DALYs were 18.16 million person years, among which 76.76 % were caused by IHD (13.94 million person years), with DALY rate as 1285.83/100 000. Among provinces, Heilongjiang showed the highest standardized DALY rate, and Zhejiang the lowest. The PAF, number of deaths, rates on mortality and DALY caused by high LDL-C were high among residents above 70 years old, with the DALY number as 8.56 million person years, highest seen in the age group from 50 to 69 years old. Conclusion:The burden of disease attributed to high level LDL-C was quite high and with gender, age group and interprovincial differences, in China in 2017.
