Heritability of coronary heart disease, based on the data from the Chinese adult twins
- VernacularTitle:中国成年双生子人群的冠心病遗传度估计
- Author:
Dongmeng WANG
1
;
Wenjing GAO
;
Jun LYU
;
Canqing YU
;
Shengfeng WANG
;
Zengchang PANG
;
Min YU
;
Hua WANG
;
Xianping WU
;
Zhong DONG
;
Fan WU
;
Guohong JIANG
;
Xiaojie WANG
;
Yu LIU
;
Jian DENG
;
Lin LU
;
Weihua CAO
;
Liming LI
Author Information
- Keywords: Coronary heart disease; Twin study; Heritability
- From: Chinese Journal of Epidemiology 2020;41(5):700-704
- CountryChina
- Language:Chinese
- Abstract: Objective:To analyze the heritability of coronary heart disease (CHD) among the Chinese twin adults.Methods:A total of 20 477 same-sex twin pairs aged 25 years and older from the Chinese National Twin Registry were interviewed. Structure equation model was used to estimate the heritability of CHD.Results:After adjusting for age and gender, the overall heritability of CHD was 0.75(0.68-0.81). Stratified analyses showed that genetic factors play a more important role in CHD incidence in ≥40 years or female twins. While the development of CHD was mainly influenced by environmental factors in 25-39 years or male twins.Conclusion:CHD is influenced by both genetic and environmental factors and the heritability is high.
