Risk factors and their interaction on cognitive impairment in the elderly in China: case-control study
10.3760/cma.j.cn112338-20200105-00010
- VernacularTitle:我国老年人认知异常影响因素及其交互作用病例对照研究
- Author:
Xuan WANG
1
;
Zhihui WANG
;
Shige QI
;
Mei ZHANG
;
Xiao ZHANG
;
Yunqi GUAN
;
Caihong HU
;
Limin WANG
Author Information
1. 中国疾病预防控制中心慢性非传染性疾病预防控制中心慢病危险因素监测室，北京 100050
- Keywords:
Cognition impairment;
Apolipoprotein E;
Case-control studies;
Dysosmia
- From:
Chinese Journal of Epidemiology
2020;41(5):705-710
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the association of apolipoprotein E (ApoE) genotype, sleep problem, olfaction problems, chronic constipation and their interactions on cognitive impairment in the elderly aged 60 and above.Methods:A stratified multi-stage cluster sampling was used in 6 provinces (autonomous administrative regions and municipalities) to select the sample. 1 300 cases with cognitive impairment and 2 600 controls without cognitive impairment were recruited and matched according to their age, gender and resident area in a 1∶2 case-control study. A total of 3 501 people were included after data cleaning. Chi-square test and conditional logistic regression model were used for univariate analysis, multivariate analysis and interaction analysis.Results:ApoE carrying ε4 genotypes, sleep problems, smell disorders, constipation is independent risk factors of cognitive impairment in the elderly ( OR=1.44, 1.65, 2.26, 2.13, P<0.001). The additive interaction between ApoE genotype and olfaction change was statistically significant [ AP=0.45(95% CI: 0.13- 0.77), S=2.37 (95% CI: 1.08-5.24)]. The interaction between other factors with cognitive impairment was not found to be statistically significant. The above results were adjusted for occupation, tea drinking, neighborhood interaction, social activities, physical exercise, reading books and newspapers, playing cards and mahjong, memory changes and hypertension, diabetes, stroke. Conclusions:ApoE genotype, sleep problems, olfaction problems, and chronic constipation are risk factors for cognitive impairment in people 60 and older. There is a synergistic interaction effect between ApoE genotype and olfaction problems on cognitive impairment in the elderly over 60 years old.
