Causal relationship between sleep and coronary artery disease: a Mendelian randomization study
10.3760/cma.j.cn112338-20190624-00462
- VernacularTitle:睡眠与冠心病的孟德尔随机化因果关联研究
- Author:
Xue GAO
1
;
Xiaochen YANG
;
Lingxian MENG
;
Heli SUN
;
Tong WANG
Author Information
1. 山西医科大学公共卫生学院卫生统计教研室，太原 030001
- Keywords:
Coronary artery disease;
Sleep;
Mendelian randomization
- From:
Chinese Journal of Epidemiology
2020;41(4):611-614
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To understand the causal relationship between sleep and coronary artery disease (CAD).Methods:This study included six genome-wide association parts; five for sleep related traits[sleep duration (continuous variable), long sleep duration (binary variable), short sleep duration (binary variable), early-to-bed/up habit (known as 'morningness’) and frequently insomnia] and one for CAD. Heterogeneity in dependent instrument approach was used to assess and to remove the pleiotropic instruments. Generalized summary data-based Mendelian randomization was performed to estimate the causal relationships between sleep related traits and CAD. And a conservative Bonferroni was used for statistical tests.Results:Sleep duration was putatively causal for CAD ( OR=0.755, 95 %CI: 0.658-0.867, P=6.68E-05). Our results also indicated significant causal effects between both short sleep duration and frequently insomnia on CAD, with ORs as 4.251 (95 %CI: 2.396-7.541, P=7.51E-07) and 1.814 (95 %CI: 1.346-2.446, P=9.25E-05), respectively. There was no convincing evidence of causality between long sleep duration or morningness with CAD. Conclusions:Our findings suggested that both sleep duration and frequently insomnia played causal roles on CAD, indicating that disease models should include sleep duration and insomnia as potential factors for CAD to develop effective interventions.
