Influence on physical development of children aged 18 months from HIV-positive mothers for prevention mother to child transmission of HIV
10.3760/cma.j.issn.0254-6450.2020.03.014
- VernacularTitle:HIV阳性母亲接受预防艾滋病母婴传播对其所生18月龄儿童体格发育的影响
- Author:
Xianmin GE
1
;
Wenmin YANG
;
Zhiyong SHEN
;
Huanhuan CHEN
;
Bin LI
;
Qin MENG
;
Liuhong LUO
;
Huaxiang LU
;
Jinhui ZHU
;
Guanghua LAN
;
Qiuying ZHU
;
Xiuling WU
;
Guanghua HUANG
;
Botao FU
;
Zhuoxin HUANG
;
Jiawei LI
;
Jinmei CHEN
;
Zhenqiang CHEN
;
Jin YANG
;
Yu YAN
Author Information
1. 广西壮族自治区疾病预防控制中心，南宁 530028
- Keywords:
HIV/AIDS;
Preventing mother to child transmission;
Antiretroviral treatment;
Physical development
- From:
Chinese Journal of Epidemiology
2020;41(3):354-357
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore influence on physical development of children aged 18 months from HIV-positive mothers for prevention mother to child transmission of HIV (PMTCT) in Guangxi Zhuang autonomous region, and provide evidence for the improvement PMTCT program.Methods:This retrospective case control study was conducted in 554 HIV negative infants aged 18 months whose HIV positive mothers had received PMTCT services reported through PMTCT system database from January 1, 2010 to December 31, 2017 and 1 109 healthy infants born in 2017, whose mothers were healthy, in Lingshan, Luzhai, and Hengxian counties, ranking top three counties with high HIV infection prevalence, in Guangxi. PMTCT data and physical development data such as height, weight and head circumference of children aged 18 months were collected. The physical dysplasia in the infants was defined as at least one of the three main indicators of height, weight and head circumference below the normal range.Results:The number of HIV-positive mother and their infants in the case group were 667 and 554 respectively, and the PMTCT rates were 91.15 % (608/667) and 96.57 % (535/554) respectively. HIV positive rate, mortality rate and mother to child transmission rate of the infants aged 18 months were 1.44 % (8/554), 3.07 % (17/554) and 1.91 % (8/418) respectively, and the physical examination results of the infants aged 18 months showed that the physical dysplasia rate was 30.51 % (169/554). Among the 1 109 infants in the control group, the physical dysplasia rate was 9.83 % (109/1 109). The difference between the case group and the control group was significant ( P<0.01). Conclusion:The PMTCT rates of HIV positive mother and their children were more than 90.00 %, respectively. However, poor physical development rate of infants aged 18 months were more than 30.00 %. The possible influence of PMTCT on physical development of the infants aged 18 months of HIV positive mother’s needs to be further studied.
