Effect of preoperative oral ibuprofen on postoperative pain after dental implantation: a randomized controlled trial
10.3760/cma.j.cn112144-20240430-00174
- VernacularTitle:术前口服布洛芬对种植体植入术后疼痛影响的随机对照研究
- Author:
Kang GAO
1
;
Xuezhu WEI
;
Bin ZHAO
;
Zhiguang LIU
;
Conglin DU
;
Xin WANG
;
Yao WANG
;
Changying LIU
;
Dezheng TANG
;
Qi ZHANG
;
Ruiqing WU
;
Mingming OU
;
Wei LI
;
Qian CHENG
;
Yilin XIE
;
Pan MA
;
Jun LI
;
Hao WANG
;
Zuomin WANG
;
Su CHEN
;
Wei ZHANG
;
Jian ZHOU
Author Information
1. 首都医科大学口腔医学院特诊特需科，北京 100050
- Keywords:
Analgesia;
Pain;
Preemptive analgesia;
Pain management;
Ibuprofen;
Dental implant;
Implant surgery
- From:
Chinese Journal of Stomatology
2024;59(8):777-783
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the effect of preemptive analgesia with ibuprofen on postoperative pain following single posterior tooth implantation, aiming to provide a clinical reference for its application.Methods:A multicenter, randomized, double-blind, placebo-controlled parallel-group trial was conducted. A total of 82 participants were included in the trial, meeting the eligibility criteria from April 2022 to April 2024 at the Capital Medical University School of Stomatology (40 cases), Beijing TianTan Hospital, Capital Medical University (22 cases), Beijing Chao-Yang Hospital, Capital Medical University (20 cases). Participants were randomly assigned in a 1∶1 ratio to either the ibuprofen group or the control group, with each group comprising 41 individuals. Participants in the ibuprofen group received 300 mg of sustained-release ibuprofen capsules orally 15 min before surgery, while the control group received a placebo. Both groups received the same postoperative analgesic regimen for 3 days. Pain scores were assessed using the numerical rating scale at 30 min, 4 h, 6 h, 8 h, 24 h, 48 h, and 72 h postoperatively, and the additional use of analgesic medication was recorded from days 4 to 6 postoperatively.Results:A total of 82 participants were initially enrolled in the study, with 7 dropouts (4 from the control group and 3 from the ibuprofen group), resulting in 75 participants (37 in the control group and 38 in the ibuprofen group) completing the trial. There were no reports of adverse events such as nausea or vomiting among the participants. The ibuprofen group exhibited significantly lower pain scores at 4 h, 6 h and 8 h [1.0 (0.0, 2.0), 1.0 (0.0, 2.0), 1.5 (0.0, 3.0) ] postoperatively compared to the control group 4 h, 6 h and 8 h [2.0 (1.0, 3.0), 3.0 (1.5, 4.0), 2.0 (1.0, 4.0)] ( Z=-1.99, P=0.047; Z=-3.01, P=0.003; Z=-2.10, P=0.036). The proportions of patients requiring additional analgesic medication between days 4 and 6 post-surgery were 18.4% (7/38) in the ibuprofen group and 27.0% (10/37) in the control group, with no significant difference (χ 2=0.79, P=0.373). The median additional medication usage postoperatively was [0.0 (0.0, 0.0) pills] in the ibuprofen group and [0.0 (0.0, 1.0) pills] in the control group, with no significant difference ( Z=-0.78, P=0.439). Conclusions:Preemptive analgesia with ibuprofen effectively reduces postoperative pain following tooth implantation, representing a safe and effective perioperative pain management strategy.
