Research progress in dual immune regulation of neutrophils in periodontal inflammation
10.3760/cma.j.cn112144-20231105-00237
- VernacularTitle:中性粒细胞在牙周炎症中的双重免疫调控作用及研究进展
- Author:
Chengkai WANG
1
;
Hui WANG
;
Bingqing WU
;
Yi LIU
;
Zhenhua LUO
Author Information
1. 首都医科大学口腔医学院牙周科，北京 100050
- Keywords:
Periodontitis;
Neutrophils;
Respiratory burst;
Neutrophil extracellular traps;
Cell degranulation;
Phagocytosis
- From:
Chinese Journal of Stomatology
2024;59(7):721-725
- CountryChina
- Language:Chinese
-
Abstract:
Periodontitis is a chronic inflammatory condition of the periodontal tissues triggered by bacterial biofilm, leading to manifestations such as gingival bleeding, tooth mobility, and eventual exfoliation. Neutrophils exhibit a dual role throughout the course of periodontitis, both in defense against pathogens and in potentially detrimental effects on periodontal tissues. This article elucidates the intricate mechanisms underlying the dual functions of neutrophils in periodontitis, including respiratory burst, neutrophil extracellular traps (NETs) formation, degranulation, and phagocytosis. By providing a comprehensive understanding of neutrophils involvement in periodontitis, this study aims to empower clinicians with insights into the pathogenesis of periodontitis, thereby fostering novel strategies for its prevention and treatment.
