Genetic and functional research strategies of non-syndromic cleft lip with or without cleft palate in the post genome-wide association study era
10.3760/cma.j.cn112144-20230727-00039
- VernacularTitle:后全基因组关联研究时代非综合征型唇腭裂遗传学及易感基因功能学研究策略
- Author:
Yixin YANG
1
;
Mujia LI
;
Qian ZHENG
;
Bing SHI
;
Zhonglin JIA
Author Information
1. 四川大学华西口腔医院唇腭裂外科 口腔疾病防治全国重点实验室 国家口腔医学中心 国家口腔疾病临床研究中心，成都610041
- Keywords:
Cleft lip;
Cleft palate;
Non-syndromic cleft lip with or without cleft palate;
Genome-wide association study;
Polymorphism, single nucleotide;
Functional s
- From:
Chinese Journal of Stomatology
2024;59(6):634-639
- CountryChina
- Language:Chinese
-
Abstract:
The emergence of genome-wide association studies (GWAS) has greatly promoted the genetic research of non-syndromic cleft lip with or without cleft palate (NSCL/P). There have been more than 40 regions concerning NSCL/P identified by GWAS, whereas specific susceptible loci and their potential function remains unclear. In the post-GWAS era, precise localization of susceptible loci in candidate regions and exploration of underlying biological mechanism will contribute to further understanding of genetic etiology of NSCL/P. The present article reviewed the genetic and functional research strategies of NSCL/P in post-GWAS era.
