Research progress in methylation modification in tooth root development
10.3760/cma.j.cn112144-20240115-00023
- VernacularTitle:甲基化修饰在牙根发育中作用的研究进展
- Author:
Xinyan GAN
1
;
Qiwen LI
;
Quan YUAN
Author Information
1. 四川大学华西口腔医院种植科 口腔疾病防治全国重点实验室 国家口腔医学中心 国家口腔疾病临床医学研究中心，成都 610041
- Keywords:
Tooth root;
Methylation;
Histones;
DNA modification methylases;
Epigenetic inheritance
- From:
Chinese Journal of Stomatology
2024;59(5):502-506
- CountryChina
- Language:Chinese
-
Abstract:
Methylation modification is one of the most common epigenetic modification regulation in eukaryotes, including histone methylation, DNA methylation, RNA methylation, etc., which plays an important regulatory role in physiological processes and pathologic occurrence and development. Tooth root development is carried out by both epithelial and mesenchymal cells and involves a variety of cell-molecular interactions. In recent years, a large number of studies have found that methylation plays a key role in the regulation of tooth root development and expands the mechanism network of tooth root development. In this paper, we review the role and mechanism of methylation modification during root development.
