Salivary carcinoma showing thymus-like differentiation: clinicopathological analysis of 7 cases
10.3760/cma.j.cn112144-20231211-00290
- VernacularTitle:唾液腺伴胸腺样分化的癌7例临床病理分析
- Author:
Chunye ZHANG
1
;
Ting GU
;
Shu XIA
;
Yu WANG
;
Jiang LI
Author Information
1. 上海交通大学医学院附属第九人民医院口腔病理科 上海交通大学口腔医学院 国家口腔医学中心 国家口腔疾病临床医学研究中心 上海市口腔医学重点实验室 上海市口腔医学研究所，上海 200011
- Keywords:
Pathology, clinical;
Salivary;
Carcinoma showing thymus-like differentiation;
Antigens, CD5
- From:
Chinese Journal of Stomatology
2024;59(5):479-485
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the clinicopathological features of salivary carcinoma showing thymus-like differentiation(CASTLE).Methods:Cases diagnosed with salivary CASTLE from January 2020 to December 2023 were collected and selected from the Department of Oral Pathology, Shanghai Ninth People′s Hospital, Shanghai Jiao Tong University School of Medicine. A total of 7 cases of salivary CASTLE were identified. All the cases originated from parotid. There were 3 males and 4 females. The patients′ age range was 11-70 years.The clinical, microscopic, immunohistochemical and prognostic features of these cases were analyzed.Results:The duration of disease ranged from 1 month to 1 year, and 1 patient had facial numbness and 1 with swelling sensation occasionally. Radiographically, 4 cases showed malignant signs. Microscopically, 4 cases involved in parotid gland, and all the tumors had different degrees of lymphoid tissue background. The tumor cells arranged in nests, 5 cases with lymphoepithelial carcinoma-like and 2 cases with squamous cell carcinoma morphology. The tumor cells expressed CD5 and CD117 proteins diffusely in lymphoepithelial carcinoma-like cases. However, the tumor cells expressed CD5 diffusely and CD117 focally in cases with squamous cell carcinoma morphology. All the cases had no Epstein-Barr virus infection. Among the 6 patients with follow-up information, all of them underwent postoperative radiotherapy, and none of them had local recurrence and lymph node metastasis.Conclusions:Salivary CASTLE is a rare tumor, it should be distinguished from lymphoepithelial carcinoma and squamous cell carcinoma. The patients often have better prognosis and CD5 protein expression has a valuable role in the differential diagnosis.
