Theory and practice of mesenchymal condensation directing tooth development and regeneration
10.3760/cma.j.cn112144-20240131-00060
- VernacularTitle:间充质凝聚指导牙发育与再生的理论与实践
- Author:
Bingdong SUI
1
;
Yan JIN
Author Information
1. 第四军医大学口腔医院组织工程研发中心 口颌系统重建与再生全国重点实验室 国家口腔疾病临床医学研究中心 陕西省口腔疾病国际联合研究中心，西安 710032
- Keywords:
Tissue engineering;
Mesenchymal stem cells;
Mesenchymal condensation;
Stem cell aggregate;
Tooth regeneration
- From:
Chinese Journal of Stomatology
2024;59(5):418-425
- CountryChina
- Language:Chinese
-
Abstract:
Mesenchymal stem cells, under spatiotemporal regulation of genes and microenvironment, are capable of spontaneously aggregating into dense regions, a phenomenon known as mesenchymal condensation. Mesenchymal condensation is an evolutionarily conserved developmental event that is critical in initiating morphogenesis of teeth and systemic organs. Mesenchymal stem cells hold the intrinsic ability to self-assemble in culture, and the generation of stem cell aggregates based on this property that mimics developmental mesenchymal condensation has become a potent and promising approach in regenerative medicine. This review discusses the mesenchymal condensation principles and its role as well as mechanism in tooth morphogenesis, as well as the engineering strategies for constructing mesenchymal stem cell aggregates and their application experience in tooth regeneration. It aims to start from the perspective of "development-inspired regeneration" and provide insights into understanding stem cell developmental biology and establishing new organ regenerative strategies.
