Role of innate lymphoid cells in oral squamous cell carcinoma microenvironment
10.3760/cma.j.cn112144-20240129-00041
- VernacularTitle:固有淋巴样细胞在口腔鳞状细胞癌微环境中的作用探讨
- Author:
Liping LIU
1
;
Yue ZHA
;
Jinyu WANG
;
Lianyi XU
;
Xu QIN
Author Information
1. 华中科技大学同济医学院口腔医学院，武汉 430030
- Keywords:
Carcinoma, squamous cell;
Innate lymphoid cell;
Tumor microenvironment;
Killer cells, natural;
Tumor progression;
Tumor development
- From:
Chinese Journal of Stomatology
2024;59(4):394-399
- CountryChina
- Language:Chinese
-
Abstract:
Oral squamous cell carcinoma (OSCC) is the most common oral malignancy. It has a high incidence, strong invasion ability, easy metastasis, poor curative effect, and poor prognosis. Innate lymphoid cells (ILCs) are an important part of immune cells located in the mucosal barrier, which play an important role in the occurrence, development and outcome of tumors. ILCs are the key cells for decoding the regulatory mechanism of tumor microenvironment and the signatures for tumor progression. This paper reviewed the latest progress on ILCs, summarized the possible characteristics and functions of ILCs in the microenvironment of OSCC, and explored the relationship between ILCs and the occurrence, development and immunotherapy of OSCC.
