Research progress in N 6-methyladenosine modification in the field of stomatology
10.3760/cma.j.cn112144-20230721-00030
- VernacularTitle:N 6-腺苷酸甲基化修饰在口腔领域中的研究进展
- Author:
Qiaozhi JIANG
1
;
Renchuan TAO
Author Information
1. 广西医科大学附属口腔医院牙周黏膜科 广西壮族自治区卫生健康委员会口腔感染性疾病防治重点实验室，南宁 530021
- Keywords:
Methylation;
N 6-methyladenosine;
RNA modification;
Mouth
- From:
Chinese Journal of Stomatology
2024;59(3):279-287
- CountryChina
- Language:Chinese
-
Abstract:
N 6-methyladenosine (m6A) is the most abundant and widely distributed internal RNA modification in eukaryotic cells, and it is involved in the regulation of gene expression and biological processes in many cells. In recent years, studies on the role of m6A modification in oral cavity have emerged gradually. Existing researches show that m6A-related proteins are involved in the regulation of oral squamous cell carcinoma and its resistance to therapy. Methyltransferase-like 3 regulates apoptosis and autophagy of chondrocytes in inflammation, the angiogenesis and osteogenesis during distraction osteogenesis of endothelial progenitor cells, inflammatory response of dental pulp cells, the differentiation and osteogenesis of dental pulp stem cells, the development of tooth roots and the differentiation of bone marrow mesenchymal stem cells and so on. Moreover, m6A modification may also be related to the occurrence and development of periodontitis, oral ulcers and oral submucosal fibrosis. These studies have provided new ideas for the pathogenesis of various oral diseases and the diagnosis and treatment of oral bone tissue repair and regeneration. This paper reviews the recent research progress on the role of m6A modification in the field of stomatology and summarize the current research status of m6A in the field of stomatology, in order to provide reference for the further research of m6A function and mechanism in the field of stomatology.
