Progress and prospects of liquid-liquid phase separation in developmental diseases
10.3760/cma.j.cn112144-20230718-00021
- VernacularTitle:液-液相分离在发育性疾病中的研究进展
- Author:
Zhuoxuan WU
1
;
Jiahe WANG
;
Chenchen ZHOU
Author Information
1. 四川大学华西口腔医院儿童口腔科 口腔疾病防治全国重点实验室 国家口腔医学中心 国家口腔疾病临床医学研究中心，成都 610041
- Keywords:
Cell compartmentation;
Liquid-liquid separation;
Developmental diseases;
Membraneless organelles;
Intrinsically disordered regions
- From:
Chinese Journal of Stomatology
2024;59(2):191-196
- CountryChina
- Language:Chinese
-
Abstract:
Membrane-bound organelles as well as membrane-free compartments exist in eukaryotic cells, which divide the nucleus and cytoplasm into distinct subregions and allow specific biochemical reactions to occur. The physiological mechanisms of membrane-bound organelles have been extensively characterized, but the formation and function of membrane-free compartments have not been thoroughly studied. Over the past decade, significant progress had been made in the studies about the role of liquid-liquid phase separation (LLPS) in the formation of membrane-free organelles. LLPS which serves as an aggregated separation mechanism for cellular biochemical reactions, is associated with a variety of physiological processes such as signal transduction and gene transcriptional regulation; while aberrant LLPS may contribute to the occurrence of developmental diseases. The present review investigates the role of LLPS as a mechanism of aggregation and segregation of cellular biochemical responses. The mechanisms of LLPS development and recent advances in the relationships between aberrant LLPS and developmental diseases are forward discussed, as well as how these advances may aid in the development of LLPS-based therapies.
