Research progress in molecular mechanism of palatal development
10.3760/cma.j.cn112144-20230718-00018
- VernacularTitle:腭部发育分子机制的研究进展
- Author:
Binqing WANG
1
;
Tao SONG
Author Information
1. 中国医学科学院 北京协和医学院 整形外科医院唇腭裂中心，北京 100144
- Keywords:
Palate;
Cleft palate;
Embryonic development;
Molecular mechanism;
Transcription factors;
Cell signaling
- From:
Chinese Journal of Stomatology
2024;59(1):110-115
- CountryChina
- Language:Chinese
-
Abstract:
Cleft palate is one of the most common maxillofacial birth defects, which can occur alone or accompany with many known deformities. Palatal selves need to complete the process of vertical growth, elevation, adhesion and fusion in a specific time window of embryo development. Any abnormality in this process will lead to cleft palate. Although previous studies have identified many molecular networks that regulate the growth, location and fusion of palatal selves, there are still many unknown mechanisms for palatal development. The pathogenesis of cleft palate has not been clarified so far. In recent years, the molecular research on palate development has been deepened continuously. Here we summarize major recent advances and integrate the genes and molecular pathways with the cellular and morphogenetic processes of palatal shelf growth, patterning, elevation, adhesion, and fusion, in order to comprehensively understand the genotype-phenotype functional relationship and provide assistance in formulating effective prevention strategies for cleft palate disease.
