Research progress in the diagnosis and management of proliferative verrucous leukoplakia
10.3760/cma.j.cn112144-20230816-00088
- VernacularTitle:增殖性疣状白斑诊断和治疗的研究新进展
- Author:
Yulang XIE
1
;
Chunyu LI
;
Sixin JIANG
;
Wenjin SHI
;
Xiaobo LUO
;
Qianming CHEN
Author Information
1. 四川大学华西口腔医院口腔黏膜病科 口腔疾病防治全国重点实验室 国家口腔医学中心 国家口腔疾病临床医学研究中心 中国医学科学院口腔黏膜癌变与防治创新单元, 成都 610041
- Keywords:
Leukoplakia, oral;
Mouth mucosa;
Proliferative verrucous leukoplakia;
Oral potentially malignant disorders;
Diagnosis;
Management.
- From:
Chinese Journal of Stomatology
2023;58(10):1083-1090
- CountryChina
- Language:Chinese
-
Abstract:
Proliferative verrucous leukoplakia (PVL) is one of the oral potentially malignant disorders (OPMD) with the highest malignant potential. PVL tends to be easily misdiagnosed owing to the resemblance in clinical manifestations between PVL and other diseases such as oral leukoplakia or oral lichen planus. PVL is considered as a special type of oral leukoplakia by some scholars, which is characterized by its tendency of recurrence and metastasis, along with its high risk of malignant transformation. So far, the accurate clinic diagnosis and management of PVL are still intractable due to the lack of definite histopathological definition, unified diagnostic criteria and effective treatment modalities. This review aims to provide the clinical practitioners with a series of advices on the clinical diagnosis and management of PVL by systematically reviewing the diagnostic logistics, therapeutic strategies, malignant transformation detection based on tremendous relevant data and evidence-based medicine.
