Research advances in preclinical models of oral mucosal melanoma
10.3760/cma.j.cn112144-20221105-00571
- VernacularTitle:口腔黏膜黑色素瘤临床前模型的研究进展
- Author:
Xinyi HUANG
1
;
Chaoji SHI
;
Zhiyuan ZHANG
Author Information
1. 上海交通大学医学院附属第九人民医院口腔颌面-头颈肿瘤科 上海交通大学口腔医学院 国家口腔医学中心 国家口腔疾病临床医学研究中心 上海市口腔医学重点实验室 上海市口腔医学研究所 中国医学科学院口腔颌面再生医学创新单元，上海200011
- Keywords:
Melanoma;
Oral mucosal melanoma;
Mucosal melanoma;
Preclinical model;
Patient-derived tumor xenograft;
Patient-derived tumor organoid;
Personalized treatmen
- From:
Chinese Journal of Stomatology
2023;58(8):852-857
- CountryChina
- Language:Chinese
-
Abstract:
Oral mucosal melanoma (OMM), a subtype of melanoma which is commonly found in the eastern Asian populations, progresses with unclear pathogenesis, high malignancy and poor prognosis. Constructing different types of preclinical models for OMM, which simulate clinical characteristics such as tumor invasion and metastasis, assists screening and efficacy-evaluation of drugs. This would promote personalized treatments for patients with OMM. However, lack of preclinical models makes one of the critical obstacles that hinder the recognition of mucosal melanoma and block the treatment breakthrough in mucosal melanoma. In recent years, certain progress has been made in the construction and application of OMM preclinical models. Various OMM preclinical models have been successfully constructed and carried out for further research, assisting in excavating personalized treatment strategies. In this review, we will summarize the latest progress in the researches on OMM preclinical models.
