Research progress in the relationship between prediabetes mellitus and periodontitis

VernacularTitle:糖尿病前期与牙周炎关系的研究进展
Author: Minkui LIN ¹ ; Lili LI ; Fuhua YAN
Author Information

1. 福建医科大学口腔医学院·附属口腔医院牙周科　福建省口腔疾病研究重点实验室　福建省口腔生物材料工程技术研究中心　福建省高校口腔医学重点实验室　福建医科大学口腔医学研究院　福建医科大学口腔组织工程研究中心，福州　350001
Keywords: Prediabetic state; Periodontitis; Oxidative stress; Systemic inflammation; Gut microbiota
From: Chinese Journal of Stomatology 2022;57(6):629-634
CountryChina
Language:Chinese
Abstract: Prediabetes mellitus (Pre-DM) is an intermediate state of hyperglycemia between normal blood glucose homeostasis and type 2 diabetes mellitus (T2DM). More than half of adults in China suffer from Pre-DM. Periodontitis is a chronic inflammatory disease mainly caused by microorganisms in dental plaque. It shares common risk factors and interacts with non-communicable diseases such as diabetes mellitus. Pre-DM may increase the risk of periodontitis, and the latter may also influence the development and progress of diabetes. Oxidative stress, systemic inflammation and intestinal flora are the main mechanisms by which Pre-DM and periodontitis interconnect with each other. This article mainly reviews the relationship between Pre-DM and periodontitis and potential related mechanisms, providing a new basis for the prevention and treatment of both.