Research progress in mitochondrial transfer mediated by tunneling nanotube in the field of tumor
10.3760/cma.j.cn112144-20210320-00131
- VernacularTitle:隧道纳米管途径介导线粒体转运在肿瘤领域的研究进展
- Author:
Nengwen HUANG
1
;
Xianghe QIAO
;
Longjiang LI
Author Information
1. 四川大学华西口腔医院头颈肿瘤外科 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心，成都 610041
- Keywords:
Mitochondrial diseases;
Mitochondrial transfer;
Tunneling nanotube;
Energy metabolism;
Molecular targeted therapy
- From:
Chinese Journal of Stomatology
2021;56(10):1045-1049
- CountryChina
- Language:Chinese
-
Abstract:
Mitochondria, as the main site of cell metabolism and energy generation, contains the genome encoding the respiratory chain-associated complexes. Deletions or mutations of mitochondria will lead to mitochondrial respiratory chain deficiencies and these deficiencies play an important role in metabolic reprogramming which is considered as one of the important features of tumorigenesis and development. Many studies have found that tunneling nanotube (TNT), a well-established mitochondrial transfer pathway, is able to restore mitochondrial respiratory deficiencies. This review article focuses on the occurrence of mitochondrial transfer, the mechanism of TNT formation and the promising therapeutic targets acting on mitochondrial transfer.
