Research progress on the role of extracellular vesicles in the diagnosis and treatment of chronic periodontitis
10.3760/cma.j.cn112144-20200618-00353
- VernacularTitle:细胞外囊泡在慢性牙周炎疾病进程及诊疗中作用的研究进展
- Author:
Xiaoxuan ZHANG
1
;
Xing WANG
;
Xiuyun REN
Author Information
1. 山西医科大学口腔医学院·口腔医院口腔颌面外科 口腔疾病防治与新材料山西省重点实验室，太原 030001
- Keywords:
Chronic periodontitis;
Exosomes;
Extracellular vesicles;
Pathogenesis;
Diagnosis and treatment
- From:
Chinese Journal of Stomatology
2021;56(4):385-389
- CountryChina
- Language:Chinese
-
Abstract:
Chronic periodontitis is a disease of periodontal supporting tissue infection caused by various causes. It was believed that the oral bacteria were the initiator of chronic periodontitis, and the host immune factors would affect the developing process and outcome of periodontitis, although the specific regulatory mechanism was not completely clear. Extracellular vesicles, subcellular components produced by cell paracrine, may carry a variety of genetic information to mediate intercellular communication. Extracellular vesicles have been found to be closely related to tumors and cardiovascular, cerebrovascular, neurological and immune system diseases and provide a research pathway for the early diagnosis, etiological therapy and vaccine design. Various extracellular vesicles are released from periodontal ligament stem cells, gingival mesenchymal stem cells, bone marrow mesenchymal stem cells, osteoblasts, osteoclasts, immune cells and periodontal pathogenic bacteria. These extracellular vesicles release for mutual communication and regulation, and further affect the pathogenesis of chronic periodontitis. In the present article, the characteristics of extracellular vesicles from periodontal tissues and periodontal pathogenic bacteria were introduced, the research progress of extracellular vesicles involved in the regulation of chronic periodontitis was reviewed and the potential value of extracellular vesicles in the diagnosis and treatment of chronic periodontitis was prospected.
