Research progress in the interaction between Treponema denticola and microorganisms of subgingival plaque
10.3760/cma.j.cn112144-20200528-00305
- VernacularTitle:齿垢密螺旋体与龈下菌斑微生物相互作用的研究进展
- Author:
Peien HUANG
1
;
Daonan SHEN
;
Yafei WU
Author Information
1. 四川大学华西口腔医院牙周病科 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心，成都 610041
- Keywords:
Treponema denticola;
Symbiosis;
Quorum sensing;
Adhesion and coaggregation;
Changes in metabolism
- From:
Chinese Journal of Stomatology
2021;56(4):380-384
- CountryChina
- Language:Chinese
-
Abstract:
Treponema denticola (Td) is a gram-negative anaerobic bacterium closely related to the occurrence and development of periodontal disease and it accounts for a considerable proportion of mature plaque. As a later colonizer of the subgingival plaque biofilm, Td may have complex interactions with earlier and concurrent colonists including symbiotic relationship as while as synergistic or antagonistic effects under the regulation of quorum sensing molecules. Adhesin and coaggregation, mediated by a series of surface molecules, are the basis of the interaction. These interactions are ultimately manifested as gene expression changes in metabolism and virulence, in which are mainly metabolism changes with up- or down-regulation of multiple enzymes related to amino acid metabolism. This article reviews the related researches on the interaction between Td and microorganisms of subgingival plaque.
