Research progress of polymicrobial synergy and dysbiosis in periodontitis
10.3760/cma.j.cn112144-20200429-00239
- VernacularTitle:微生物协同作用和生态失调与牙周病关系的研究进展
- Author:
Chengzhi ZHAO
1
;
Zhu CHEN
;
Mingyun LI
Author Information
1. 四川大学华西口腔医院 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心，成都 610041
- Keywords:
Periodontitis;
Oral microbiota;
Polymicrobial synergy and dysbiosis;
Keystone pathogens;
Accessory pathogens
- From:
Chinese Journal of Stomatology
2021;56(3):301-305
- CountryChina
- Language:Chinese
-
Abstract:
Human oral cavity is colonized by various microbial communities which play an important role in the initiation and progression of periodontitis. However, it is still not clear how these microbial communities mediate the disease. With the rise of metagenomics research, polymicrobial synergy and dysbiosis (PSD) model, a new periodontitis pathogenesis mechanism, was proposed. The importance of the microbial communities acting as a whole system in the development of periodontitis is gradually recognized. Host susceptibility, as another key factor in the initiation of the disease, is vital in PSD model. This article reviews the mechanisms of the PSD model and its research progress in periodontitis as well as some other diseases and briefly highlights the positive significance in terms of prevention and treatment of periodontitis in order to provide insights and perspectives for the future periodontal researches.
